Selected compounds existing in grapefruit are identified to inhibit CYP450 3A4 and will raise the bioavailability of swallowed fentanyl (reportedly as many as 75% of a dose) andGrownup:Patches produce fentanyl in doses that range from: 12-100 mcg/hr. Doses really should be separately titrated according to earlier utilization of opioids. Opioid-naiv